-
Gene info
Although increased levels of Pgp are likely to contribute to MDR in at least some tumor types, it has become evident that alternative, non-Pgp-mediated mechanisms of MDR exist. The multidrug resistance-associated protein (MRP1) has been identified by Cole and Deeley. The amino acid identity between MRP1 and Pgp is only 15%, and the homology to chloride channel CFTR only 19%. Paulusma, et al., cloned the cDNA for rat canalicular multispecific organic anion transporter (cMOAT or MRP2) which turned out to be a novel liver specific homolog of human MRP1. Recently, by screening database of human expressed sequences tags, Kool identified three new homologs of MRP1, called MRP3, MRP4 and MRP5. Suitable for use in Immunohistochemistry and Western Blot. Other applications have not been tested. Recognizes human MRP4. Does not recognize other species.
-
Gene names
ABCC4, EST170205, MOAT-B, Multidrug resistance protein 4, MOATB, MRP4
-
Antibodie s label
unlabelled serum
-
Purity
Affinity Chromatography
-
Ab raised in
Rabbit
-
Type
Polyclonal
-
Immunoglobulin
IgG
-
Spicific to
Recognizes human MRP4. Does not recognize other species.
-
Antigen
ABCC4 antibody was made against a peptide near the N-Terminus of ABCC4 (Human).
-
Immuno application
Western Blot, immuno-histo-chemistry
-
Antibody advice
ABCC4 antibody can be used in ELISA, Western Blot starting at 1:1000 - 1:2000, and immunohistochemistry starting at 5 ug/mL.
-
Suspention pH azide
Borate buffer, protein stabilizer.
-
Keep at
Store ABC4 antibody at 4 grades C or -20 grades C. As with all antibodies avoid freeze/thaw cycles.
-
Works with
Human
-
Omim nr
206729914
-
Ncbi nr
O15439
-
Vial with antibody
in solution
-
NCBI GENE nr
10257
-
GENE symbol
ABCC4
-
Antigene name
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
-
Source
Homo sapiens
-
Protein nr
O15439
-
-
-
-
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
-
Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translation
anticorps
-
Gene target
-
Gene symbol
ABCC4
-
Short name
anti-ABCC4 Antibody
-
Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
-
Alternative name
Antibody toATP-binding cassette, sub-family C (cystic fibrosis transmembrane conductance regulator (adenosine triphosphate-binding cassette sub-family C, member 7)/MRP), member 4 (antibody to-)
-
Alternative technique
antibodies
-
Alternative to gene target
ATP-binding cassette, sub-family C (CFTR/MRP), member 4, MOAT-B and MOATB and MRP4, ABCC4 and IDBG-42534 and ENSG00000125257 and 10257, ATPase activity, Plasma membranes, Abcc4 and IDBG-186342 and ENSMUSG00000032849 and 239273, BT.93156 and IDBG-632162 and ENSBTAG00000032603 and 515333
-
