Netrin receptor DCC / DCC Recombinant Protein

• Background:

  Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

• NCBI Gene ID:

  1630

• Swiss Prot:

  P43146

• Accession Number:

  NP_005206.2

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Purity:

  >90% as determined by SDS-PAGE.

• Buffer:

  50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  144.1 kDa

• Applications Notes:

  This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 144.1 kDa. The protein migrates as 140-160 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  DCCnetrin1receptor

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Netrin receptor DCC, DCC, IGDCC1, netrin receptor DCC

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3