GUCY2C / Guanylyl cyclase C Recombinant Protein

• Background:

  GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

• NCBI Gene ID:

  102130850

• Accession Number:

  XP_005570270.1

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Purity:

  >90% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  72.6 kDa

• Applications Notes:

  This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 72.6 kDa. The protein migrates as 95-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  Guanylatecyclase2C

• NCBI Organism:

  Macaca fascicularis

• Background Reference 01:

  Magee MS, et al. Cancer Immunol Res. 2018. 6 (5) :509-516.

• Background Reference 02:

  Li P, et al. Cancer Res. 2017. 77 (18) :5095-5106.

• Background Reference 03:

  Arshad N, et al. J Biol Chem. 2013. 288 (6) :3907-17.

• Other Product Names:

  GUCY2C, GUC2C, STAR, STA receptor, hSTAR, GC-C

• Tested Applications:

  ELISA, WB

• Species:

  Cynomolgus monkey

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3