Products for Research Use Only
RegisterLogin

Seneciphylline

CAT: 0804-HY-N1282-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-N1282-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Seneciphylline is an orally effective hepatotoxic inducer. Seneciphylline is metabolized by CYP450 enzymes into active intermediates, which covalently bind to intracellular biomacromolecules such as proteins and DNA to form adducts, which in turn trigger a series of toxic reactions, such as inducing cell apoptosis and damaging mitochondrial function. Seneciphylline can be used in hepatotoxicity research[1][2].
CAS Number
480-81-9
UNSPSC
12352005
Hazard Statement
H300+H310+H330
Target
Cytochrome P450; Glutathione S-transferase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/seneciphylline.html
Purity
99.93
Solubility
DMSO : 7.69 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O[C@]1([H])CCN2[C@]1([H])C(COC([C@](C)(O)C(C/3)=C)=O)=CC2)C3=C/C
Molecular Formula
C18H23NO5
Molecular Weight
333.38
Precautions
H300+H310+H330
References & Citations
[1]Kakrani HK, et al. Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats. J Ethnopharmacol. 1984 Dec;12 (3) :271-8.|[2]Wang W, et al. Seneciphylline, a main pyrrolizidine alkaloid in Gynura japonica, induces hepatotoxicity in mice and primary hepatocytes via activating mitochondria-mediated apoptosis. J Appl Toxicol. 2020 Nov;40 (11) :1534-1544.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Related Products

CatalogName
HY-N1283Seneciphyllinine

Alternative Products

CatalogName
GTR19166802-01Seneciphylline
MBS5784117Seneciphylline, hydrochloride
sc-472626Seneciphylline-D3
466024-01Seneciphylline N-Oxide
RM-S109001-01Seneciphylline Impurity 1
RM-S109002-01Seneciphylline Impurity 2

Popular Products