Calpeptin

• Description :

  Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets[1]. Calpeptin is also an inhibitor of cathepsin K[2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Cathepsin; Proteasome

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/Calpeptin.html

• Concentration :

  10mM

• Purity :

  99.17

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@H](C=O)CCCC)=O)CC(C)C

• Molecular Formula :

  C20H30N2O4

• Molecular Weight :

  362.46

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Tsujinaka T, et al. Synthesis of a new cell penetrating calpain inhibitor (calpeptin) . Biochem Biophys Res Commun. 1988 Jun 30;153 (3) :1201-8.|[2]Catalano JG, et al. Design of small molecule ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett. 2004 Feb 9;14 (3) :719-22.|[3]Tabata C, et al. The calpain inhibitor calpeptin prevents pulmonary fibrosis in mice. Clin Exp Immunol. 2010 Dec;162 (3) :560-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cathepsin K

• CAS Number :

  [117591-20-5]