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KCNK9 (TASK-3) rabbit pAb

CAT: 0855-ES20696-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Description
This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
UniProt
Q9NPC2
Swiss Prot
Q9NPC2
Reactivity
Human; Rat; Mouse
Immunogen
Synthetic Peptide of KCNK9 (TASK-3) AA range: 220-270
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF
Concentration
1 mg/ml
Dilution
WB 1:1000-2000, IHC 1:100-200
Molecular Weight
42kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
42kD
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein .
Other Product Names
Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3; TWIK-related acid-sensitive K (+) channel 3; Two pore potassium channel KT3.2; Two pore K (+) channel KT3.2)
Gene ID (Human)
51305

UniProtKB · Q9NPC2

Potassium channel subfamily K member 9

KCNK9_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NPC2
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KCNK9
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q2M290, Q540F2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneCell projectionMembraneMitochondrionMitochondrion inner membrane

Disease

Disease variantIntellectual disability

PTM

Glycoprotein

Molecular function

Ion channelPotassium channelSodium channel

Biological process

Ion transportPotassium transportSodium transportTransport

Ligand

Metal-bindingPotassiumSodium

Domain

TransmembraneTransmembrane helix

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