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Carprofen

CAT: 0804-HY-B1227-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1227-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.
CAS Number
53716-49-7
UNSPSC
12352005
Hazard Statement
H301
Target
Autophagy; COX; Endogenous Metabolite; FAAH
Type
Reference compound
Related Pathways
Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Carprofen.html
Concentration
10mM
Purity
99.94
Solubility
DMSO : 87.5 mg/mL (ultrasonic)
Smiles
O=C(O)C(C)C1=CC(NC2=C3C=C(Cl)C=C2)=C3C=C1
Molecular Formula
C15H12ClNO2
Molecular Weight
273.71
Precautions
H301
References & Citations
[1]Favia AD, et al. Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor. J Med Chem. 2012 Oct 25;55 (20) :8807-26.|[2]Waldherr K, et al. In vitro cytoprotective effects of acetylsalicylic acid, carprofen, meloxicam, or robenacoxib against apoptosis induced by sodium nitroprusside in canine cruciate ligament cells. Am J Vet Res. 2012 Nov;73 (11) :1752-8.|[3]Sessions JK, et al. In vivo effects of carprofen, deracoxib, and etodolac on prostanoid production in blood, gastric mucosa, and synovial fluid in dogs with chronic osteoarthritis. Am J Vet Res. 2005 May;66 (5) :812-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-1; COX-2

Alternative Products

CatalogName
FC31969-01Carprofen
sc-211027Carprofen Ethyl Ester (Carprofen Impurity)

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