Gboxin

• Description :

  Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase. Antitumour activity[1].

• CAS Number :

  [2101315-36-8]

• UNSPSC :

  12352005

• Target :

  ATP Synthase; Mitochondrial Metabolism; Oxidative Phosphorylation

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Gboxin.html

• Concentration :

  10mM

• Purity :

  98.23

• Solubility :

  DMSO : 32.5 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)

• Smiles :

  O=C(O[C@H]1[C@H](C(C)C)CC[C@@H](C)C1)CN2C(CC)=[N+](C)C3=CC=CC=C23.[Cl-]

• Molecular Formula :

  C22H33ClN2O2

• Molecular Weight :

  392.96

• References & Citations :

  [1]Shi Y, et al. Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Nature. 2019 Mar;567 (7748) :341-346.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported