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Macozinone

CAT: 0804-HY-12903-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12903-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect[1][2].
CAS Number
1377239-83-2
Product Name Alternative
PBTZ169
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/PBTZ169.html
Purity
98.46
Solubility
DMSO : 6.4 mg/mL (ultrasonic)
Smiles
O=C1C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2SC(N3CCN(CC4CCCCC4)CC3)=N1
Molecular Formula
C20H23F3N4O3S
Molecular Weight
456.48
Precautions
H302, H315, H319, H335
References & Citations
[1][3] Makarov V et al. Towards a new combination therapy for tuberculosis with next generation benzothiazinones. EMBO Mol Med. 2014 Mar;6 (3) :372-83.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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