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AC1903

CAT: 0804-HY-122051-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-122051-01Size:5 mg
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Description
AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 suppresses severe proteinuria and prevents podocyte loss in focal segmental glomerulosclerosis (FSGS) rat model[1].
CAS Number
[831234-13-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ac1903.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C1(NCC2=CC=CO2)=NC3=CC=CC=C3N1CC4=CC=CC=C4
Molecular Formula
C19H17N3O
Molecular Weight
303.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Yiming Zhou, et al. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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