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C004019

CAT: 0804-HY-138669-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138669-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C004019 is a BBB-penetrable and small-molecule PROTAC that targets tau. C004019 can simultaneously recruit tau and E3 ligase, and effectively clear tau proteins by promoting the ubiquitination and proteasome-dependent degradation of tau, thereby improving synaptic and cognitive functions in Alzheimer's disease (AD) mice. C004019 can be used in the research of AD and tau protein-related diseases. (Pink: Ligand for target protein ; Black: linker (HY-140189) ; Blue: E3 Ligase Ligand (HY-138678) )
CAS Number
2417159-57-8
UNSPSC
12352005
Target
PROTACs; Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling; PROTAC
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/c004019.html
Purity
99.72
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1[C@H](C[C@@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCNC(CN(C4=NC(N5CCN(CCC5)C(C)=O)=NC(NCCC6=CC=CS6)=N4)C)=O)=O
Molecular Formula
C49H70N12O9S2
Molecular Weight
1035.29
References & Citations
[1]Wang W, et al. A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. Theranostics. 2021 Mar 11;11 (11) :5279-5295.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19211807-01C004019

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