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Dihydrocapsaicin

CAT: 0804-HY-N0361-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0361-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat[1][2][3].
CAS Number
19408-84-5
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
Akt; Apoptosis; Bcl-2 Family; Caspase; PI3K; Reactive Oxygen Species (ROS) ; TRP Channel
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dihydrocapsaicin.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)CCCCCCC(NCC1=CC=C(O)C(OC)=C1)=O
Molecular Formula
C18H29NO3
Molecular Weight
307.43
Precautions
H301, H315, H319, H335
References & Citations
[1]Gao F, et al. Impairment in function and expression of transient receptor potential vanilloid type 4 in Dahl salt-sensitive rats: significance and mechanism. Hypertension. 2010 Apr;55 (4) :1018-25.|[2]Dihydrocapsaicin, et al. Dihydrocapsaicin (DHC) enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat. Brain Res. 2017 Sep 15;1671:18-25.|[3]Adams MJ, et al. Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation. Thromb Res. 2009 Dec;124 (6) :721-3.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Bcl-xL; Caspase 3; PI3K; TRPV1

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