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MM11253

CAT: 0804-HY-108530-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-108530-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists[1][3].
CAS Number
345952-44-5
UNSPSC
12352005
Target
RAR/RXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mm11253.html
Purity
98.21
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C2C=C(C3(C4=CC=C5C(C)(C)CCC(C)(C)C5=C4)SCCS3)C=CC2=C1)O
Molecular Formula
C28H30O2S2
Molecular Weight
462.67
References & Citations
[1]M I Dawson, et al. Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition. Int J Cancer. 2001 Jan 1;91 (1) :8-21.|[2]Q Le, et al. Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene. 2000 Mar 9;19 (11) :1457-65.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

MM 11253
CAS Number345952-44-5
PubChem CID10389639
IUPAC Name6-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dithiolan-2-yl]naphthalene-2-carboxylic acid
Molecular FormulaC28H30O2S2
Molecular Weight462.7
XLogP8.3
Topological Polar Surface Area87.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count32
Formal Charge0
Complexity710
SMILES
CC1(CCC(C2=C1C=CC(=C2)C3(SCCS3)C4=CC5=C(C=C4)C=C(C=C5)C(=O)O)(C)C)C
InChI
InChI=1S/C28H30O2S2/c1-26(2)11-12-27(3,4)24-17-22(9-10-23(24)26)28(31-13-14-32-28)21-8-7-18-15-20(25(29)30)6-5-19(18)16-21/h5-10,15-17H,11-14H2,1-4H3,(H,29,30)
InChIKey
DPVGXUNWCVEIGT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of MM 11253
CAS: 345952-44-5
CID: 10389639
Formula: C28H30O2S2
MW: 462.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight462.7
XLogP38.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass462.16872254
Monoisotopic Mass462.16872254
Topological Polar Surface Area87.9 Ų
Heavy Atom Count32
Formal Charge0
Complexity710
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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