Pentachloropseudilin

CAT: 0804-HY-115669-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-115669-01Size:5 mg

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Description

Pentachloropseudilin (Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of Myo1s (class 1 myosins) with IC50s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β (TGF-β) -stimulated signaling, with an IC50 of 0.1 to 0.2 μM for TGF-β[1][2].

CAS Number

69640-38-6

Product Name Alternative

Antibiotic A 15104 Y; PClP

UNSPSC

12352005

Target

Myosin; TGF-β Receptor

Type

Reference compound

Related Pathways

Cytoskeleton; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pentachloropseudilin.html

Purity

98.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C(C2=C(Cl)C(Cl)=C(Cl)N2)C=C(Cl)C=C1Cl

Molecular Formula

C10H4Cl5NO

Molecular Weight

331.41

References & Citations

[1]Chinthalapudi K, et al. Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. J Biol Chem. 2011;286 (34) :29700-29708.|[2]Chung CL, et al. Pentachloropseudilin Inhibits Transforming Growth Factor-β (TGF-β) Activity by Accelerating Cell-Surface Type II TGF-β Receptor Turnover in Target Cells. Chembiochem. 2018;19 (8) :851-864. |[3]Cota Teixeira S, et al. Pentachloropseudilin Impairs Angiogenesis by Disrupting the Actin Cytoskeleton, Integrin Trafficking and the Cell Cycle. Chembiochem. 2019;20 (18) :2390-2401.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

Pentachloropseudilin

structure in first source

CAS Number	69640-38-6
PubChem CID	3053233
IUPAC Name	2,4-dichloro-6-(3,4,5-trichloro-1H-pyrrol-2-yl)phenol
Molecular Formula	C10H4Cl5NO
Molecular Weight	331.4
XLogP	5.5
Topological Polar Surface Area	36
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Heavy Atom Count	17
Formal Charge	0
Complexity	281

SMILES

C1=C(C=C(C(=C1C2=C(C(=C(N2)Cl)Cl)Cl)O)Cl)Cl

InChI

InChI=1S/C10H4Cl5NO/c11-3-1-4(9(17)5(12)2-3)8-6(13)7(14)10(15)16-8/h1-2,16-17H

InChIKey

FBRLLYYPGGXCKT-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 69640-38-6

CID: 3053233

Formula: C10H4Cl5NO

MW: 331.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	331.4
XLogP3	5.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Exact Mass	330.870602
Monoisotopic Mass	328.873552
Topological Polar Surface Area	36 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	281
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
TRC-P273410-25MG	Pentachloropseudilin

Pentachloropseudilin

Chemical Information

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