Desformylflustrabromine hydrochloride
CAT:
804-HY-107675-06
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Desformylflustrabromine hydrochloride
- CAS Number: 951322-11-5
- UNSPSC Description: Desformylflustrabromine hydrochloride is a selective agonist of α4β2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC50 of 6.48.
- Target Antigen: nAChR
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
- Applications: Neuroscience-Neuromodulation
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/Desformylflustrabromine_hydrochloride.html
- Purity: 99.77
- Solubility: DMSO : ≥ 105 mg/mL|H2O : 5 mg/mL (ultrasonic)
- Smiles: CNCCC1=C(C(C)(C)C=C)NC2=CC(Br)=CC=C12.[H]Cl
- Molecular Weight: 357.72
- References & Citations: [1]Nadezhda German, et al. Deconstruction of the α4β2 Nicotinic Acetylchloine (nACh) Receptor Positive Allosteric Modulator des-Formylflustrabromine (dFBr). J Med Chem. 2011 Oct 27;54(20):7259-67.|[2]Weltzin MM, et al. Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 Subunit. J Pharmacol Exp Ther. 2015 Aug;354(2):184-94.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported