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RO1138452

CAT: 0804-HY-108912-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108912-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RO1138452 is a potent and selective IP (prostacyclin) receptor antagonist. RO1138452 displays high affinity for IP receptors. In human platelets, pKi is 9.3±0.1; in a recombinant IP receptor system, pKi is 8.7±0.06.
CAS Number
221529-58-4
Product Name Alternative
CAY10441
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/RO1138452.html
Purity
99.26
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)
Smiles
CC(C)OC1=CC=C(CC2=CC=C(NC3=NCCN3)C=C2)C=C1
Molecular Formula
C19H23N3O
Molecular Weight
309.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Bley KR, et al. RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br J Pharmacol. 2006 Feb;147 (3) :335-45.|[2]Ayer LM, et al. 4,5-Dihydro-1H-imidazol-2-yl) -[4- (4-isopropoxy-benzyl) -phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP) -receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CXCL9 and CXCL10 release. J Pharmacol Exp Ther. 2008 Feb;324 (2) :815-26.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IP

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CatalogName
BA5698-50RO1138452

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