MStab1-1.26, InVivoPure

CAT: 0013-GTR18521165-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR18521165-01Size:10 mg

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Description

MStab1-1.26, + is a mouse monoclonal antibody against mouse Stabilin-1 (UniProt entry: Q8R4Y4), also known as Clever-1 or FEEL-1. Stabilin-1 is a scavenger receptor expressed by sinusoidal endothelial cells (ECs) in the liver, lymph nodes, spleen, and bone marrow [1]. Stabilin-1 is expressed in human breast cancer and supports tumor growth [2]. It is found on subset of macrophages that mediate tissue homeostasis and is involved in liver fibrosis [3]. mStab1-1.26 or mStabilin-1 (clone 1.26) is first mentioned by Schledzewski et al. (2006) [4]. To generate the antibody, a recombinant mouse stabilin-1 fragment (residues 1–710 of Q8R4Y4) fused to mouse IgG2b-Fc was purified from stably-transfected HEK293 cells and used to immunize stabilin-1 knockout mice. mStab1-1.26 recognizes stabilin-1 in rat and mouse. The antibody is produced exclusively under serum-free conditions from hybridoma and purified through one-step purification with Protein-G affinity chromatography.

Product Name Alternative

STABILIN-1, FEX1, SCARH2, FEEL-1, FEEL1, FELE-1, CLEVER-1, mouse stab1

UniProt

Q8R4Y4

Reactivity

Mouse, Rat

Immunogen

Recombinant mouse Stabilin-1 fragment from HEK 293 (residues 1–710 of Q8R4Y4, fused to mouse-IgG2b-Fc

Target

Stabilin-1

Clonality

Monoclonal

Clone

1.26

Conjugation

Unconjugated

Concentration

≥ 1 mg/ mL

Purity

≥ 90 % (CGE, reducing conditions) Endotoxin level ≤ 2 EU/mg

Form

Liquid, PBS, pH 7.4, 0.2 μm sterile filtered

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Recomended Isotype: Mouse IgG1ĸ Isotype Control, Recomended Isotype Catalog: orb2568796

Tested Applications

In vivo

Host or Source

Mouse

Preservative

Liquid, PBS, pH 7.4, 0.2 μm sterile filtered

Isotype

IgG1 κ

UniProtKB · Q8R4Y4

Stabilin-1

STAB1_MOUSE · Mus musculus

View on UniProt ↗

Primary accession: Q8R4Y4
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: Stab1
Protein existence: 1: Evidence at protein level
Organism: Mus musculus (Mouse)
Taxonomy ID: 10090
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: Q8K0K6, Q8VC09

Protein keywords

Coding sequence diversity

Alternative splicing

Technical term

Direct protein sequencingReference proteome

PTM

Disulfide bondGlycoprotein

Domain

EGF-like domainLaminin EGF-like domainRepeatSignalTransmembraneTransmembrane helix

Biological process

Inflammatory response

Cellular component

Membrane

Molecular function

Receptor

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MBS393841-01	Hexacosanoic-26,26,26-D3 Acid
MBS3920061-01	Methyl Hexacosanoate (26,26,26-D3)