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Lumretuzumab

CAT: 0804-HY-P99304-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99304-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lumretuzumab (Anti-Human ERBB3 Recombinant Antibody) is a humanized anti-HER3 (ERBB3) monoclonal antibody. Lumretuzumab effectively inhibits the activity of key oncogenic signaling pathways such as PI3K/AKT and MAPK. Lumretuzumab has been optimized through glycosyl engineering to enhance antibody-dependent cell-mediated cytotoxicity (ADCC) . Lumretuzumab can be used to study HER3-positive, HER2-low-expressing solid tumors, especially breast cancer[1][2].
CAS Number
1448327-63-6
Product Name Alternative
Anti-Human ERBB3 Recombinant Antibody
UNSPSC
12352203
Target
Akt; EGFR; p38 MAPK; PI3K
Type
Inhibitory Antibodies
Related Pathways
JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lumretuzumab.html
Purity
99.0
Solubility
H2O
Smiles
[Lumretuzumab]
Molecular Weight
(146.92 kDa)
References & Citations
[1]Schneeweiss A, et al. Phase Ib study evaluating safety and clinical activity of the anti-HER3 antibody lumretuzumab combined with the anti-HER2 antibody pertuzumab and paclitaxel in HER3-positive, HER2-low metastatic breast cancer. Invest New Drugs. 2018 Oct;36 (5) :848-859.|[2]Collins D, et al. Direct estrogen receptor (ER) / HER family crosstalk mediating sensitivity to lumretuzumab and pertuzumab in ER+ breast cancer. PLoS One. 2017 May 11;12 (5) :e0177331.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 1
Isoform
ErbB3/HER3

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