Products for Research Use Only
RegisterLogin

RO5256390

CAT: 0804-HY-12700-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-12700-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
RO5256390 is an orally effective trace amine associated receptor 1 (TAAR1) agonist. RO5256390 exhibits pro-cognitive and antidepressant-like properties in rodent and primate models, showing similar brain activation patterns to Olanzapine. RO5256390 blocks compulsive overeating behavior in rats. RO5256390 can inhibit ATP (HY-B2176) -induced TNF secretion in mouse bone marrow-derived macrophages[1][2][3].
CAS Number
1043495-96-0
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Trace Amine-associated Receptor (TAAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ro5256390.html
Concentration
10mM
Purity
98.75
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
NC1=N[C@@H](C[C@@H](C2=CC=CC=C2)CC)CO1
Molecular Formula
C13H18N2O
Molecular Weight
218.30
Precautions
H315, H319
References & Citations
[1]Ferragud A, et al. The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats. Neuropsychopharmacology. 2017 Jun;42 (7) :1458-1470.|[2]Revel FG, et al. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry. 2013 May;18 (5) :543-56.|[3]Barnes DA, et al. TAAR1 Regulates Purinergic-induced TNF Secretion from Peripheral, But Not CNS-resident, Macrophages. J Neuroimmune Pharmacol. 2023 Jun;18 (1-2) :100-111.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
BA5823-50RO5256390

Popular Products