Nα,Nα-Bis(carboxymethyl)-L-lysine

• UNSPSC Description:

  Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study[1][2][3].

• Target Antigen:

  Taste Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/nα-nα-bis-carboxymethyl-l-lysine.html

• Purity:

  98.80

• Solubility:

  DMSO : 1.82 mg/mL (ultrasonic)

• Smiles:

  NCCCC[C@@H](C(O)=O)N(CC(O)=O)CC(O)=O

• Molecular Weight:

  262.26

• References & Citations:

  [1]Pydi SP, et al. Amino acid derivatives as bitter taste receptor (T2R) blockers. J Biol Chem. 2014;289(36):25054-25066. |[2]Sidhu C, et al. Regulation of Rac1 GTPase activity by quinine through G-protein and bitter taste receptor T2R4. Mol Cell Biochem. 2017;426(1-2):129-136. |[3]Masamoto M, et al. Yoshida R. Effects of bitter receptor antagonists on behavioral lick responses of mice. Neurosci Lett. 2020;730:135041.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  113231-05-3