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Onatasertib

CAT: 0804-HY-16956-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16956-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Onatasertib (CC-223) is a potent, selective, and orally bioavailable inhibitor of mTOR kinase, with an IC50 value for mTOR kinase of 16 nM. Onatasertib inhibits both mTORC1 and mTORC2.
CAS Number
1228013-30-6
Product Name Alternative
CC-223; ATG-008
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; mTOR
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CC-223.html
Concentration
10mM
Purity
99.13
Solubility
DMSO : ≥ 27 mg/mL
Smiles
O=C1CNC2=NC=C(C3=CC=C(C(C)(O)C)N=C3)N=C2N1[C@H]4CC[C@H](OC)CC4
Molecular Formula
C21H27N5O3
Molecular Weight
397.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Mortensen DS, et al. CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization. Mol Cancer Ther. 2015 Jun;14 (6) :1295-305.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
MTOR; mTORC1; mTORC2

Alternative Products

CatalogName
GTR19172868-01Onatasertib
C18060Onatasertib (CC 223)

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