Recombinant Human Sentrin-specific protease 1 (SENP1)

CAT: 0399-CSB-EP885787HU-01Size: 20 µgDry Ice: NoHazardous: No

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CAT#:0399-CSB-EP885787HU-01Size:20 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Product Name Alternative

Sentrin/SUMO-specific protease SENP1

Abbreviation

Recombinant Human SENP1 protein

Gene Name

SENP1

UniProt

Q9P0U3

Expression Region

1-644aa

Organism

Homo sapiens (Human)

Target Sequence

MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL

Tag

C-terminal 6xHis-tagged

Type

Developed Protein

Source

E.coli

Field of Research

Cell Biology

Relevance

Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier SUMO propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Deconjugates SUMO1 from METTL3. Desumoylates CCAR2 which decreases its interaction with SIRT1. Deconjugates SUMO1 from GPS2.

Endotoxin

Not test

Purity

Greater than 85% as determined by SDS-PAGE.

Activity

Not Test

Form

Liquid or Lyophilized powder

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Molecular Weight

80.4 kDa

Storage Conditions

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Protein Length

Full Length

UniProtKB · Q9P0U3

Sentrin-specific protease 1

SENP1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9P0U3
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: SENP1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 3.4.22.-
Processing: —
Secondary accessions: A8K7P5, Q86XC8

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Molecular function

HydrolaseProteaseThiol protease

PTM

Phosphoprotein

Biological process

Ubl conjugation pathway

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Alternative Products

Catalog	Name
MBS6005735-01	SENP1, NT (Sentrin-specific Protease 1, Sentrin/SUMO-specific Protease SENP1)
S0740-05B	SENP1, CT (Sentrin-specific Protease 1, Sentrin/SUMO-specific Protease SENP1, SEN1)
S0740-05A	SENP1, NT (Sentrin-specific Protease 1, Sentrin/SUMO-specific Protease SENP1, SEN1)
225724-01	SENP1 (Sentrin-specific Protease 1, Sentrin/SUMO-specific Protease SENP1, SEN1) discontinued
136403	SENP1, NT (Sentrin-specific Protease 1, Sentrin/SUMO-specific Protease SENP1) discontinued
S0740-05C	SENP1, NT (Sentrin-specific Protease 1, Sentrin/SUMO-specific Protease SENP1, SEN1) discontinued
MBS6498770-01	SENP1, CT (Sentrin-specific Protease 1, Sentrin/SUMO-specific Protease SENP1, SEN1) (APC)
MBS6498761-01	SENP1, NT (Sentrin-specific Protease 1, Sentrin/SUMO-specific Protease SENP1, SEN1) (FITC)
MBS6498758-01	SENP1, NT (Sentrin-specific Protease 1, Sentrin/SUMO-specific Protease SENP1, SEN1) (AP)
MBS6498779-01	SENP1, CT (Sentrin-specific Protease 1, Sentrin/SUMO-specific Protease SENP1, SEN1) (PE)