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Belimumab

CAT: 0804-HY-P9952-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P9952-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Belimumab (LymphoStat B) is a humanized IgG1λ monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research[1][2][3][4]. The component ratio of this product is Active ingredient: Excipients = 1:1.0-1:1.2.
CAS Number
356547-88-1
Product Name Alternative
LymphoStat B
UNSPSC
12352203
Target
CD20; TNF Receptor
Type
Inhibitory Antibodies
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/belimumab.html
Purity
99.40
Solubility
H2O
Smiles
[Belimumab]
Molecular Weight
(144.54 kDa)
References & Citations
[1]Hannah A Blair, et al. Belimumab: A Review in Systemic Lupus Erythematosus. Drugs. 2018 Mar;78 (3) :355-366.|[2]Stohl W, et al. The discovery and development of belimumab: the anti-BLyS-lupus connection. Nat Biotechnol. 2012 Jan 9;30 (1) :69-77.|[3]Halpern WG, et al. Chronic administration of belimumab, a BLyS antagonist, decreases tissue and peripheral blood B-lymphocyte populations in cynomolgus monkeys: pharmacokinetic, pharmacodynamic, and toxicologic effects. Toxicol Sci. 2006 Jun;91 (2) :586-99.
Shipping Conditions
Isolate blue ice and the product with bubble pack to avoid direct contact
Storage Conditions
Store at 4°C for 2 years, do not freeze
Scientific Category
Inhibitory Antibodies
Clinical Information
Launched

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