Mosperafenib

CAT: 0804-HY-145120-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-145120-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Mosperafenib is a blood-brain barrier-permeable BRAF inhibitor. Mosperafenib can be used for the study of BRAF V600-mutant solid tumors, such as colorectal cancer (CRC) [1].

CAS Number

2649372-20-1

Product Name Alternative

RG6344; RO7276389; B-Raf IN 2

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319, H332, H335

Target

Raf

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/b-raf-in-2.html

Concentration

10mM

Purity

99.27

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=C(C(F)=CC=C1NS(=O)(N2C[C@@H](CC2)F)=O)OC3=CC=C(N=CN(C4=O)C)C4=C3

Molecular Formula

C20H17F2N5O4S

Molecular Weight

461.44

Precautions

H302, H312, H315, H319, H332, H335

References & Citations

[1]Maria Vieito, et al. Abstract CT017: A phase I study evaluating safety, pharmacokinetics, and clinical activity of the novel, paradox breaker BRAF inhibitor RG6344 in patients with BRAF V600-mutant solid tumors. Cancer Res (2025) 85 (8_Supplement_2) : CT017.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

B-Raf

Mosperafenib

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