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Seladelpar

CAT: 0804-HY-19522-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19522-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Seladelpar (MBX-8025) is an orally active, potent and specific PPARδ agonist with an EC50 of 2 nM. Seladelpar shows more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively. Seladelpar can be used for the study of primary biliary cholangitis[1].
CAS Number
851528-79-5
Product Name Alternative
MBX-8025; RWJ-800025
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/MBX-8025.html
Purity
99.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)COC1=CC=C(SC[C@H](OCC)COC2=CC=C(C(F)(F)F)C=C2)C=C1C
Molecular Formula
C21H23F3O5S
Molecular Weight
444.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Bays HE, et al. MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin. J Clin Endocrinol Metab. 2011 Sep;96 (9) :2889-97.|[2]Haczeyni F, et al. The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice. Hepatol Commun. 2017 Jul 31;1 (7) :663-674.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
PPARα; PPARβ/δ

Alternative Products

CatalogName
S6635-01Seladelpar
CS-O-59393Seladelpar-d4
A20744-100Seladelpar 100mg
A20744-25Seladelpar 25mg
A20744-10Seladelpar 10mg
MBS5775912Seladelpar lysine
A20744-200Seladelpar 200mg
A20744-5Seladelpar 5mg
CS-O-59392Seladelpar-d5
CS-O-59391Seladelpar-d6

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