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Miclxin

CAT: 0804-HY-138301-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138301-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex[1].
CAS Number
2494198-61-5
Product Name Alternative
DS37262926
UNSPSC
12352005
Target
Apoptosis; Wnt; β-catenin
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/miclxin.html
Concentration
10mM
Purity
98.12
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
COC1=CC(CNC2=C3C=CC(OC)=CC3=NC(N4CC(C5=CC=CN=C5)CC4)=N2)=CC=C1
Molecular Formula
C26H27N5O2
Molecular Weight
441.52
References & Citations
[1]Ikeda H, et al. Miclxin, a Novel MIC60 Inhibitor, Induces Apoptosis via Mitochondrial Stress in β-Catenin Mutant Tumor Cells. ACS Chem Biol. 2020 Aug 21;15 (8) :2195-2204.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
BA9144-50Miclxin

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