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Gefitinib-Based PROTAC 3

CAT: 0127-BISN0057-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0127-BISN0057-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2230821-27-7
MDL Number
MFCD32062811
Purity
99%
Smiles
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCCCOCCOCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCc5ccc(cc5)c6scnc6C)C(C)(C)C
Notes
Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R) .

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MBS3603574-01Gefitinib-based PROTAC 3
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