Gefitinib-Based PROTAC 3

• MDL Number:

  MFCD32062811

• Purity:

  99%

• Smiles:

  COc1cc2ncnc (Nc3ccc (F) c (Cl) c3) c2cc1OCCCCCOCCOCCC (=O) N[C@H] (C (=O) N4C[C@H] (O) C[C@H]4C (=O) NCc5ccc (cc5) c6scnc6C) C (C) (C) C

• Notes:

  Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R) .

• CAS Number:

  2230821-27-7