MK-6892

• Description :

  MK-6892 is a potent, selective, and full agonist for the high affinity nicotinic acid (NA) receptor GPR109A. Ki and GTPγS EC50 of MK-6892 on the Human GPR109A is 4 nM and 16 nM, respectively.

• UNSPSC :

  12352005

• Target :

  GPR109A

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/MK-6892.html

• Purity :

  99.43

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  OC(C=C1)=CN=C1C2=NOC(CC(C)(C)C(NC3=C(C(O)=O)CCCC3)=O)=N2

• Molecular Formula :

  C19H22N4O5

• Molecular Weight :

  386.40

• References & Citations :

  [1]Shen HC, et al. Discovery of a biaryl cyclohexene carboxylic acid (MK-6892) : a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. J Med Chem. 2010 Mar 25;53 (6) :2666-70.|[2]Kim HY, et al. Discovery of 4- (phenyl) thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptor. Arch Pharm Res. 2015 Jun;38 (6) :1019-32.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [917910-45-3]