MK-6892

• Description:

  MK-6892 is a potent, selective, and full agonist for the high affinity nicotinic acid (NA) receptor GPR109A. Ki and GTPγS EC50 of MK-6892 on the Human GPR109A is 4 nM and 16 nM, respectively.

• UNSPSC:

  12352005

• Target:

  GPR109A

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/MK-6892.html

• Purity:

  99.43

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  OC(C=C1)=CN=C1C2=NOC(CC(C)(C)C(NC3=C(C(O)=O)CCCC3)=O)=N2

• Molecular Formula:

  C19H22N4O5

• Molecular Weight:

  386.40

• References & Citations:

  [1]Shen HC, et al. Discovery of a biaryl cyclohexene carboxylic acid (MK-6892) : a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. J Med Chem. 2010 Mar 25;53 (6) :2666-70.|[2]Kim HY, et al. Discovery of 4- (phenyl) thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptor. Arch Pharm Res. 2015 Jun;38 (6) :1019-32.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [917910-45-3]