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Basmisanil

CAT: 0804-HY-16716-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-16716-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Basmisanil (RG1662) is a highly selective orally active α subunit-containing GABAA receptors (GABAAα5) negative allosteric modulator (NAMs) . Basmisanil can inhibit GABAA-α5 with a Ki value of 5 nM and IC50 value of 8 nM, respectively. Basmisanil can be used for the research of multiple cognitive and psychiatric disorders[1].
CAS Number
1159600-41-5
Product Name Alternative
RG1662; RO5186582
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Basmisanil.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCS(CC1)(=O)=O)C2=CC=C(OCC3=C(C)ON=C3C4=CC=C(F)C=C4)N=C2
Molecular Formula
C21H20FN3O5S
Molecular Weight
445.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Joerg F Hipp, et al. Basmisanil, a highly selective GABA A-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man. Sci Rep. 2021 Apr 8;11 (1) :7700.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
MBS3600552-01Basmisanil
A21321-25Basmisanil 25mg
A21321-5Basmisanil 5mg
MBS131487Basmisanil (RG1662)
A21321-500Basmisanil 500mg
A21321-2Basmisanil 2mg
A21321-100Basmisanil 100mg
A21321-50Basmisanil 50mg
A21321-10Basmisanil 10mg
A21321-10mM-DBasmisanil 10mM * 1mL in DMSO

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