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Tomivosertib

CAT: 0804-HY-100022-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100022-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tomivosertib (eFT508) is a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib (eFT508) treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50=2-16 nM) in tumor cell lines[1]. Tomivosertib (eFT508) also dramatically downregulates PD-L1 protein abundance[2].
CAS Number
1849590-01-7
Product Name Alternative
EFT508
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
MNK; PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eFT508.html
Purity
99.92
Solubility
DMSO : 8 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C)C=C(NC2=NC=NC(N)=C2)C(N13)=O)NC43CCCCC4
Molecular Formula
C17H20N6O2
Molecular Weight
340.38
Precautions
H315, H319, H335
References & Citations
[1]Kevin R. Webster, et al. eFT508, a Potent and Selective Mitogen-Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 Inhibitor, Is Efficacious in Preclinical Models of Diffuse Large B-Cell Lymphoma (DLBCL) . Blood 2015 126:1554.|[2]Xu Y, et al. Translation control of the immune checkpoint in cancer and its therapeutic targeting. Nat Med. 2019 Feb;25 (2) :301-311.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
MNK1; MNK2

Alternative Products

CatalogName
MBS3844852-01Tomivosertib
ZYC59002-01Tomivosertib hydrochloride
207030Tomivosertib HCl
A20407-100Tomivosertib 100mg
A20407-25Tomivosertib 25mg
A20407-10Tomivosertib 10mg
A20407-5Tomivosertib 5mg
A20407-50Tomivosertib 50mg
A20407-1Tomivosertib 1mg
C13309-100mgTomivosertib (eFT-508)

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