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Seviteronel

CAT: 0804-HY-15996-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15996-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Seviteronel (VT-464) is a potent CYP17 lyase inhibitor (h-Lyase IC50=69 nM) and an AR antagonist. Seviteronel demonstrates both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition.
CAS Number
1610537-15-9
Product Name Alternative
VT-464
UNSPSC
12352005
Target
Androgen Receptor; Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/VT-464.html
Purity
99.83
Solubility
DMSO : ≥ 50 mg/mL
Smiles
FC(F)OC1=C(OC(F)F)C=C(C=CC([C@](C2=CNN=N2)(C(C)C)O)=C3)C3=C1
Molecular Formula
C18H17F4N3O3
Molecular Weight
399.34
References & Citations
[1]Rafferty SW, et al. Highly-selective 4- (1,2,3-triazole) -based P450c17a 17,20-lyase inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24 (11) :2444-7.|[2]Sankar N. Maity, et al. Abstract 4772: Efficacy of VT-464, a novel selective inhibitor of cytochrome P450 17,20-lyase, in castrate-resistant prostate cancer models. Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1|[3]Michmerhuizen AR, et al. Seviteronel, a Novel CYP17 Lyase Inhibitor and Androgen Receptor Antagonist, Radiosensitizes AR-Positive Triple Negative Breast Cancer Cells. Front Endocrinol (Lausanne) . 2020 Feb 11;11:35.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CYP17

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