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VU0424465

CAT: 0804-HY-114978-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114978-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU0424465 is a potent and partial PAM (positive allosteric modulator) -agonist for mGlu5 mediated iCa2+ mobilization. VU0424465 exhibits high affinity at MPEP allosteric binding site, with a Ki value of 11.8 nM. VU0424465 is also a agonist for pERK1/2 in cortical neurons[1][2].
CAS Number
1428630-85-6
Product Name Alternative
Monobromobimane, 2-Ethyl-3,5-dimethylpyrazine-13C11
UNSPSC
12352005
Target
MGluR; PERK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0424465.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C)C(O)(C)C)C1=NC=C(C=C1)C#CC2=CC=CC(F)=C2
Molecular Formula
C19H19FN2O2
Molecular Weight
326.36
References & Citations
[1]Sengmany K, et al. Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery. Neuropharmacology. 2017;115:60-72.|[2]Rook JM, Noetzel MJ, Pouliot WA, et al. Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity. Biol Psychiatry. 2013;73 (6) :501-509.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5

Alternative Products

CatalogName
BA4411-5VU0424465

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