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Bosutinib (Standard)

CAT: 0804-HY-10158RSize: InquireDry Ice: NoHazardous: No
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CAT#:0804-HY-10158RSize:Inquire
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
380843-75-4
UNSPSC Description
Bosutinib (Standard) is the analytical standard of Bosutinib. This product is intended for research and analytical applications. Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC50 of 1.2 nM and 1 nM, respectively[1].
Target Antigen
Autophagy; Bcr-Abl; Src
Type
Reference Standards
Related Pathways
Autophagy;Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bosutinib-standard.html
Smiles
CN1CCN(CC1)CCCOC2=C(C=C3C(NC4=CC(OC)=C(C=C4Cl)Cl)=C(C=NC3=C2)C#N)OC
Molecular Weight
530.45
References & Citations
[1]Jorge E Cortes, et al. Bosutinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: results from the BELA trial. J Clin Oncol. 2012 Oct 1;30(28):3486-92.|[2]Miriam Puttini, et al. In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells. Cancer Res. 2006 Dec 1;66(23):11314-22.
Shipping Conditions
Room temperature

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