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Cnicin

CAT: 0804-HY-137984-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137984-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cnicin is an orally bioavailable sesquiterpene lactone. Cnicin has antibacterial and antiproliferative properties and induces apoptosis in primary myeloma cells. Cnicin also exhibits activity against SARS-CoV-2. Cnicin inhibits the viral replication of SARS CoV-2 with an IC50 of 1.18 μg/mL. Cnicin can promote functional nerve regeneration[1][2][3][4][5].
CAS Number
24394-09-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cnicin.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C([C@@H](O)CO)=C)O[C@@H](C/C(C)=C/CC1)[C@](C2=C)([H])[C@@](OC2=O)([H])/C=C1\CO
Molecular Formula
C20H26O7
Molecular Weight
378.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Jöhrer K, et al. Antimyeloma activity of the sesquiterpene lactone cnicin: impact on Pim-2 kinase as a novel therapeutic target. J Mol Med (Berl) . 2012 Jun;90 (6) :681-93.|[2]Alhadrami HA, et al. Cnicin as an Anti-SARS-CoV-2: An Integrated In Silico and In Vitro Approach for the Rapid Identification of Potential COVID-19 Therapeutics. Antibiotics (Basel) . 2021 May 7;10 (5) :542.|[3]Philipp Gobrecht, et al. Cnicin promotes functional nerve regeneration. Phytomedicine. 2024 Jul:129:155641.|[4]Sura Baykan Erel, et al. Secondary metabolites of Centaurea calolepis and evaluation of cnicin for anti-inflammatory, antioxidant, and cytotoxic activities. Pharm Biol. 2011 Aug;49 (8) :840-9. |[5]Sandra M Bach, et al. Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin. Nat Prod Commun. 2011 Feb;6 (2) :163-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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