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Pelitrexol

CAT: 0804-HY-14530-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14530-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), a purine biosynthetic enzyme. Pelitrexol also inhibits mTORC1 by reducing GTP-bound Rheb level, a mTORC1 obligate activator. Pelitrexol shows robust tumor growth suppression in mice[1].
CAS Number
446022-33-9
Product Name Alternative
AG 2037
UNSPSC
12352005
Target
Antifolate
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AG_2037.html
Concentration
10mM
Purity
98.07
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC(C)=C(CC[C@H](CN2)CC3=C2N=C(N)NC3=O)S1)=O
Molecular Formula
C20H25N5O6S
Molecular Weight
463.51
References & Citations
[1]Emmanuel N, et al. Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase. Cell Rep. 2017 Jun 27;19 (13) :2665-2680.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
WSA02233-01Pelitrexol
MBS3842192-01Pelitrexol (AG-2037)
A17217-1Pelitrexol (AG-2037) 1mg
A17217-50Pelitrexol (AG-2037) 50mg
A17217-5Pelitrexol (AG-2037) 5mg
A17217-25Pelitrexol (AG-2037) 25mg
A17217-100Pelitrexol (AG-2037) 100mg
A17217-10Pelitrexol (AG-2037) 10mg
A17217-2Pelitrexol (AG-2037) 2mg
A17217-10mM-DPelitrexol (AG-2037) 10mM * 1mL in DMSO

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