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Benzbromarone

CAT: 0804-HY-B1135-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1135-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Benzbromarone is an orally active anti-gout agent. Benzbromarone has anti-infammatory, anti-oxidative stress and nephroprotective effects. Benzbromarone can be used for the research of hyperuricemia and gout[1][2][3][4].
CAS Number
3562-84-3
UNSPSC
12352005
Hazard Statement
H301
Target
Apoptosis; Bcl-2 Family; Caspase; HSP; Interleukin Related; JNK; Keap1-Nrf2; NF-κB; SOD; Xanthine Oxidase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Benzbromarone.html
Concentration
10mM
Purity
99.81
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=CC(Br)=C(O)C(Br)=C1)C2=C(CC)OC3=CC=CC=C23
Molecular Formula
C17H12Br2O3
Molecular Weight
424.08
Precautions
H301
References & Citations
[1]Huang Z, et al. The protective effects of benzbromarone against propofol-induced inflammation and injury in human brain microvascular endothelial cells (HBMVECs) [J]. Neurotoxicity Research, 2021, 39 (5) : 1449-1458.|[2]Roos N J, et al. The uricosuric benzbromarone disturbs the mitochondrial redox homeostasis and activates the NRF2 signaling pathway in HepG2 cells [J]. Free Radical Biology and Medicine, 2020, 152: 216-226.|[3]Sun P, et al. Benzbromarone aggravates hepatic steatosis in obese individuals [J]. Biochimica et Biophysica Acta (BBA) -Molecular Basis of Disease, 2018, 1864 (6) : 2067-2077.|[4]Abdel-Razek E A N, et al. Benzbromarone mitigates cisplatin nephrotoxicity involving enhanced peroxisome proliferator-activated receptor-alpha (PPAR-α) expression [J]. Life sciences, 2020, 243: 117272.|[5]Park J G, et al. Benzbromarone Induces Targeted Degradation of HSP47 Protein and Improves Hypertrophic Scar Formation [J]. Journal of Investigative Dermatology, 2023.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Bcl-2; Caspase 3; Caspase 8; Caspase 9; IL-1; IL-8

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