NSC 185058

• Description :

  NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. Inhibition of ATG4B using NSC 185058 markedly attenuates autophagic activity[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Atg4; Autophagy

• Type :

  Reference compound

• Related Pathways :

  Autophagy

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/NSC_185058.html

• Purity :

  99.46

• Solubility :

  DMSO : ≥ 125 mg/mL

• Smiles :

  S=C(C1=NC=CC=C1)NC2=NC=CC=C2

• Molecular Formula :

  C11H9N3S

• Molecular Weight :

  215.27

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Huang T, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11;32 (6) :840-855.e8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [39122-38-8]