RO5263397

• Description:

  RO5263397 is a potent, selective, and orally available TAAR1 agonist, with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition. Antidepressant-like effect[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Trace Amine-associated Receptor (TAAR)

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ro5263397.html

• Purity:

  98.87

• Solubility:

  DMSO : 260 mg/mL (ultrasonic)

• Smiles:

  CC1=C([C@@H]2N=C(N)OC2)C=CC=C1F

• Molecular Formula:

  C10H11FN2O

• Molecular Weight:

  194.21

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Galley G, et al. Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists.ACS Med Chem Lett. 2015 Dec 30;7 (2) :192-7.|[2]Schwartz MD, et al. Trace Amine-Associated Receptor 1 Regulates Wakefulness and EEG Spectral Composition.Neuropsychopharmacology. 2017 May;42 (6) :1305-1314.|[3]Espinoza S, et al. Biochemical and Functional Characterization of the Trace Amine-Associated Receptor 1 (TAAR1) Agonist RO5263397.Front Pharmacol. 2018 Jun 21;9:645.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1357266-05-7]