Thiabendazole

• Description :

  Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling[1][2][3][4][5].

• Product Name Alternative :

  Tiabendazole; 2- (4-Thiazolyl) benzimidazole

• UNSPSC :

  12352005

• Hazard Statement :

  H410

• Target :

  Caspase; CDK; Interleukin Related; MDM-2/p53; Mitochondrial Metabolism; Parasite; VEGFR

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/Thiabendazole.html

• Concentration :

  10mM

• Purity :

  99.94

• Solubility :

  DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

• Smiles :

  C1(C2=CSC=N2)=NC3=CC=CC=C3N1

• Molecular Formula :

  C10H7N3S

• Molecular Weight :

  201.25

• Precautions :

  H410

• References & Citations :

  [1]Cha, H.J., et al., Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. PLoS Biol, 2012. 10 (8) : p. e1001379.|[2]Zhang, J., et al., Thiabendazole, a well-known antifungal drug, exhibits anti-metastatic melanoma B16F10 activity via inhibiting VEGF expression and inducing apoptosis. Pharmazie, 2013. 68 (12) : p. 962-8.|[3]Budetić M, et al. Review of Characteristics and Analytical Methods for Determination of Thiabendazole. Molecules. 2023 May 6;28 (9) :3926. |[4]Park J, et al. Developmental defects induced by thiabendazole are mediated via apoptosis, oxidative stress and alteration in PI3K/Akt and MAPK pathways in zebrafish. Environ Int. 2023 Jun;176:107973. |[5]Elgebaly SA, et al. Thiabendazole-induced suppression of renal damage in a murine model of autoimmune disease. Am J Pathol. 1984 May;115 (2) :204-11. |[6]Motwadie ME, et al. Modulation of immune functions, inflammatory response, and cytokine production following long-term oral exposure to three food additives; thiabendazole, monosodium glutamate, and brilliant blue in rats. Int Immunopharmacol. 2021 Sep;98:107902.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  Caspase 3; Caspase 9; CDK1; CDK2; IL-1; IL-10; IL-13; IL-6

• CAS Number :

  [148-79-8]