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Vamikibart

CAT: 0804-HY-P990012-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P990012-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vamikibart (RG6179) is a monoclonal antibody targeting IL-6 that can be used to inhibit uveal macular edema (UME) and reduce retinal leakage. Vamikibart can reduce anterior chamber (AC) cell density, indicating a reduction in intraocular inflammation. Vamikibart can also be used to assess the leakage dynamics of ultra-wide-angle fluorescein angiography (UWFA) in the UME model to quantify changes in retinal leakage reflecting the effect of UME inhibition[1][2].
CAS Number
2744320-12-3
Product Name Alternative
EBI-031
UNSPSC
12352203
Target
Interleukin Related
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vamikibart.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
[Vamikibart]
Molecular Weight
(145.96 kDa)
References & Citations
[1]Sharma, et al. Longitudinal Quantitative Anterior Chamber Cell Analysis Following Vamikibart Intravitreal Therapy in Patients with Uveitic Macular Edema from the DOVETAIL Clinical Trial. Investigative Ophthalmology & Visual Science 65.7 (2024) : 3028-3028.|[2]Cakir, et al. Longitudinal quantitative ultra-widefield fluorescein angiography leakage dynamics in patients with uveitic macular edema following intravitreal anti-IL-6 therapy with vamikibart. Investigative Ophthalmology & Visual Science 65.7 (2024) : 2628-2628.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3

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