5-Methoxytryptamine

• Description:

  5-Methoxytryptamine, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine is also a potent antioxidant and has radioprotective action[1][2][3].

• Product Name Alternative:

  O-Methylserotonin

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  5-HT Receptor; Drug Metabolite; Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/2-5-methoxy-1h-indol-3-yl-ethanamine.html

• Purity:

  99.91

• Solubility:

  DMSO : 200 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)

• Smiles:

  COC1=CC2=C(NC=C2CCN)C=C1

• Molecular Formula:

  C11H14N2O

• Molecular Weight:

  190.25

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]J Yamada, et al. Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor. Eur J Pharmacol. 1997 Apr 4;323 (2-3) :235-40. |[2]S Bayari, et al. Fourier transform infrared spectra and molecular structure of 5-methoxytryptamine, N-acetyl-5-methoxytryptamine and N-phenylsulfonamide-5-methoxytryptamine. Spectrochim Acta A Mol Biomol Spectrosc. 2003 Apr;59 (6) :1255-63.|[3]D A Craig, et al. 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum. Naunyn Schmiedebergs Arch Pharmacol. 1990 Jul;342 (1) :9-16.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Apolipoprotein D; Human Endogenous Metabolite; mLAG-3; MUC2; MUC3; Prostaglandin D Synthase; α-1 microglobulin

• CAS Number:

  608-07-1