Mirogabalin

• Description:

  Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.

• Product Name Alternative:

  DS5565

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H335

• Target:

  Calcium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Mirogabalin.html

• Purity:

  99.22

• Solubility:

  H2O : 7.71 mg/mL (ultrasonic)

• Smiles:

  O=C (O) C[C@]1 (CN) [C@]2 ([H]) C=C (CC) C[C@]2 ([H]) C1

• Molecular Formula:

  C12H19NO2

• Molecular Weight:

  209.29

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Vinik A, et al. Efficacy and safety of Mirogabalin (DS-5565) for the treatment of diabetic peripheral neuropathic pain: a randomized, double-blind, placebo- and active comparator-controlled, adaptive proof-of-concept phase 2 study. Diabetes Care. 2014 Dec|[2]Hutmacher MM, et al. Exposure-response modeling of average daily pain score, and dizziness and somnolence, forMirogabalin (DS-5565) in patients with diabetic peripheral neuropathic pain. J Clin Pharmacol. 2016 Jan;56 (1) :67-77.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Citation 01:

  Brain Behav Immun. 2021 Jul:95:344-361.|Molecules. 2023 Nov 30;28 (23) :7862.|Pharmaceuticals (Basel) . 2022 Jan 13;15 (1) :88.|Pharmaceuticals (Basel) . 2023 Jul 19;16 (7) :1023.|Cell Commun Signal. 2024 Feb 1;22 (1) :92.

• CAS Number:

  1138245-13-2