Mirogabalin

• Description :

  Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.

• Product Name Alternative :

  DS5565

• UNSPSC :

  12352211

• Hazard Statement :

  H315, H319, H335

• Target :

  Calcium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Mirogabalin.html

• Purity :

  99.22

• Solubility :

  H2O : 7.71 mg/mL (ultrasonic)

• Smiles :

  O=C(O)C[C@]1(CN)[C@]2([H])C=C(CC)C[C@]2([H])C1

• Molecular Formula :

  C12H19NO2

• Molecular Weight :

  209.29

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Vinik A, et al. Efficacy and safety of Mirogabalin (DS-5565) for the treatment of diabetic peripheral neuropathic pain: a randomized, double-blind, placebo- and active comparator-controlled, adaptive proof-of-concept phase 2 study. Diabetes Care. 2014 Dec|[2]Hutmacher MM, et al. Exposure-response modeling of average daily pain score, and dizziness and somnolence, forMirogabalin (DS-5565) in patients with diabetic peripheral neuropathic pain. J Clin Pharmacol. 2016 Jan;56 (1) :67-77.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Citation 01 :

  Brain Behav Immun. 2021 Jul:95:344-361.|Molecules. 2023 Nov 30;28 (23) :7862.|Pharmaceuticals (Basel) . 2022 Jan 13;15 (1) :88.|Pharmaceuticals (Basel) . 2023 Jul 19;16 (7) :1023.|Cell Commun Signal. 2024 Feb 1;22 (1) :92.

• CAS Number :

  [1138245-13-2]