Mirogabalin

• Product Name Alternative:

  DS5565

• UNSPSC Description:

  Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.

• Target Antigen:

  Calcium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Mirogabalin.html

• Purity:

  99.31

• Solubility:

  DMSO : < 1 mg/mL|H2O : 7.71 mg/mL (ultrasonic)

• Smiles:

  O=C(O)C[C@]1(CN)[C@]2([H])C=C(CC)C[C@]2([H])C1

• Molecular Weight:

  209.289

• References & Citations:

  [1]Vinik A, et al. Efficacy and safety of Mirogabalin (DS-5565) for the treatment of diabetic peripheral neuropathic pain: a randomized, double-blind, placebo- and active comparator-controlled, adaptive proof-of-concept phase 2 study. Diabetes Care. 2014 Dec|[2]Hutmacher MM, et al. Exposure-response modeling of average daily pain score, and dizziness and somnolence, forMirogabalin (DS-5565) in patients with diabetic peripheral neuropathic pain. J Clin Pharmacol. 2016 Jan;56(1):67-77.Brain Behav Immun. 2021 Jul;95:344-361.|Molecules. 2023 Nov 30, 28(23), 7862.|Pharmaceuticals. 2022, 15(1), 88.|Pharmaceuticals. 2023 Jul 19, 16(7), 1023.|Cell Commun Signal. 2024 Feb 1;22(1):92.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  1138245-13-2