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NCT02

CAT: 0804-HY-W181530-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W181530-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NCT02 is a molecular glue degrader based on the E3 ubiquitin ligase DDB1 that targets CDK12 and its binding partner CCNK. NCT02 triggers the ubiquitination and proteasomal degradation of CCNK, thereby downregulating CDK12 protein levels and inhibiting its downstream signaling pathways. NCT02 can induce tumor cell apoptosis, arrest the cell cycle, and selectively inhibit the proliferation of colorectal cancer cells carrying TP53 defects or belonging to the consensus molecular subtype CMS4. NCT02 has the potential to inhibit tumor growth in in vitro and in vivo models[1][2][3].
CAS Number
790245-61-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; CDK; Ligands for E3 Ligase; Molecular Glues
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nct02.html
Purity
98.14
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC=C(C)S1)CC2=COC3=CC4=C(CCC4)C=C32
Molecular Formula
C17H16N2O2S
Molecular Weight
312.39
Precautions
H315, H319, H335
References & Citations
[1]Dieter SM, et al. Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Rep. 2021;36 (3) :109394.|[2]Lei P, et al. Current progress and novel strategies that target CDK12 for drug discovery. Eur J Med Chem. 2022 Oct 5;240:114603.|[3]Weagel E G, et al. Molecular glues: enhanced protein-protein interactions and cell proteome editing. Medicinal Chemistry Research, 2022, 31 (7) : 1068-1087.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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CatalogName
BA3774-5NCT02

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