9-cis-Retinoic acid-d5

9-cis-Retinoic acid-d5

• UNSPSC Description: 9-cis-Retinoic acid-d5 is the deuterium labeled 9-cis-Retinoic acid. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities[1][2][3][4][5][6].
• Target Antigen: Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds; RAR/RXR
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease;Others;Vitamin D Related/Nuclear Receptor
• Field of Research: Cancer; Inflammation/Immunology; Neurological Disease
• Purity: 98.64
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CC(/C=C/C(C(C)(CCC1([2H])[2H])C)=C1C([2H])([2H])[2H])=C/C=C/C(C)=C/C(O)=O
• Molecular Weight: 305.47
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Raul Rosas, et al. Retinoids Augment Thiazolidinedione PPARγ Activation in Oral Cancer Cells. Anticancer Res. 2020 Jun;40(6):3071-3080.|[3]Hua Yang, et al. Effects of 9-cis-retinoic Acid on the Proliferation and Apoptosis of Cutaneous T-cell Lymphoma Cells. Anticancer Drugs. 2019 Jan;30(1):56-64.|[4] Zhiqing Yuan, et al. 9-cis-retinoic Acid Elevates MRP3 Expression by Inhibiting Sumoylation of RXRα to Alleviate Cholestatic Liver Injury. Biochem Biophys Res Commun. 2018 Sep 3;503(1):188-194.|[5]V M Manzano, et al. Human Renal Mesangial Cells Are a Target for the Anti-Inflammatory Action of 9-cis Retinoic Acid. Br J Pharmacol. 2000 Dec;131(8):1673-83.|[6]Gro H Mathisen, et al. Delayed Translocation of NGFI-B/RXR in Glutamate Stimulated Neurons Allows Late Protection by 9-cis Retinoic Acid. Biochem Biophys Res Commun. 2011 Oct 14;414(1):90-5.
• Shipping Conditions: Dry Ice
• Storage Conditions: -80°C, protect from light, stored under nitrogen
• Clinical Information: No Development Reported