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Recombinant Human Rock-2 Protein (Sumo Tag)

CAT: 0763-PDEH101129-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0763-PDEH101129-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
Abbreviation
Rock-2
Synonyms
ROCK 2; ROCK2; ROK alpha; ROKalpha; Rho kinase 2; Rho-associated; Rho-associated protein kinase 2; Rock II; Rock2; Rock2m
UniProt
O75116
Accession Number
O75116
Expression System
E.coli
Tag
N-Sumo
Sequence
Thr1212-Ser1388
Field of Research
Cell Biology; Cardiovascular; Signal Transduction
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
32.3 kDa
Observed Molecular Weight
38 kDa
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Species
Human

UniProtKB · O75116

Rho-associated protein kinase 2

ROCK2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75116
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ROCK2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.39
Processing
—
Secondary accessions
Q53QZ0, Q53SJ7, Q9UQN5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-bindingZinc

Biological process

Biological rhythms

Cellular component

Cell membraneCytoplasmCytoskeletonMembraneNucleus

Domain

Coiled coilZinc-finger

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein

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