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A1899

CAT: 0804-HY-103067-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103067-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A1899 is a potent and highly selective blocker of the K2P channel TASK-1. A1899 has IC50 values of 35.1 nM and 7 nM for TASK-1 channels expressed in oocytes and CHO cells, respectively. A1899 is also an IKur blocker that can be used for the research of cardiovascular diseases[1][2].
CAS Number
498577-46-1
Product Name Alternative
S20951
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/a1899.html
Purity
99.72
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NCC1=CC=C(C=C1F)F)C2=CC=CC=C2C3=CC=CC=C3CNC(CC4=CC=C(C=C4)OC)=O
Molecular Formula
C30H26F2N2O3
Molecular Weight
500.54
Precautions
H302, H315, H319
References & Citations
[1]Streit AK, et al. A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J Biol Chem. 2011 Apr 22;286 (16) :13977-84. |[2]Knobloch K, et al. Electrophysiological and antiarrhythmic effects of the novel I (Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I (Kr) blockers dofetilide, azimilide, d, l-sotalol and ibutilide. Naunyn Schmiedebergs Arch Pharmacol. 2002 Nov;366 (5) :482-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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