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Relutrigine

CAT: 0804-HY-148792-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148792-01Size:1 mg
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Description
Relutrigine (PRAX-562) is an orally active inhibitor of persistent sodium channel. Relutrigine potently and preferentially inhibits persistent INa induced by ATX-II (Nav 1.5 activator) or the SCN8A mutation N1768D with IC50 values of 141 nM and 75 nM, respectively. Relutrigine exhibits potent use-dependent block and reduces neuronal intrinsic excitability. Relutrigine has effective anticonvulsant activity[1].
CAS Number
2392951-29-8
Product Name Alternative
PRAX-562
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/relutrigine.html
Concentration
10mM
Purity
99.13
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(OCC(F)(F)F)N=CC(C2=CN3C(C(F)(OCC)F)=NN=C3C=N2)=C1
Molecular Formula
C15H11F6N5O2
Molecular Weight
407.27
References & Citations
[1]Kahlig KM, et al. The novel persistent sodium current inhibitor PRAX-562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers. Epilepsia. 2022 Mar;63 (3) :697-708.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Alternative Products

CatalogName
BA6980-5Relutrigine

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