Melatonin Receptor Type 1A (human recombinant)

• Description:

  Melatonin Receptor Type 1A (human recombinant)_x000D_ Catalog number: B2017259_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 10 µg_x000D_ Molecular Weight or Concentration: 44.8 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: ˆ’80°C_x000D_ Keywords: MT1_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Ebisawa T, Kajimura N, Uchiyama M, Katoh M, Sekimoto M, Watanabe T, Ozeki Y, Ikeda M, Jodoi T, Sugishita M, Iwase T, Kamei Y, Kim K, Shibui K, Kudo Y, Yamada N, Toyoshima R, Okawa M, Takahashi K, Yamauchi T. Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders Biochem Biophys Res Commun. 1999 Sep 7;262(3):832-7._x000D_ 2: Amin M, Gragnoli C. Melatonin receptor 1A (MTNR1A) gene linkage and association to type 2 diabetes in Italian families Eur Rev Med Pharmacol Sci. 2023 May;27(10):4688-4692._x000D_ 3: Wu N, Carpino G, Ceci L, Baiocchi L, Francis H, Kennedy L, Zhou T, Chen L, Sato K, Kyritsi K, Meadows V, Ekser B, Franchitto A, Mancinelli R, Onori P, Gaudio E, Glaser S, Alpini G. Melatonin receptor 1A, but not 1B, knockout decreases biliary damage and liver fibrosis during cholestatic liver injury Hepatology. 2022 Apr;75(4):797-813._x000D_ 4: Sulkava S, Muggalla P, Sulkava R, Ollila HM, Peuralinna T, Myllykangas L, Kaivola K, Stone DJ, Traynor BJ, Renton AE, Rivera AM, Helisalmi S, Soininen H, Polvikoski T, Hiltunen M, Tienari PJ, Huttunen HJ, Paunio T. Melatonin receptor type 1A gene linked to Alzheimer's disease in old age Sleep. 2018 Jul 1;41(7):zsy103._x000D_ 5: Postolache TT, Al Tinawi QM, Gragnoli C. The melatonin receptor genes are linked and associated with the risk of polycystic ovary syndrome J Ovarian Res. 2024 Jan 13;17(1):17._x000D_ 6: Daher G, Santos-Bezerra DP, Cavaleiro AM, Pelaes TS, Admoni SN, Perez RV, Machado CG, do Amaral FG, Cipolla-Neto J, Correa-Giannella ML. Rs4862705 in the melatonin receptor 1A gene is associated with renal function decline in type 1 diabetes individuals Front Endocrinol (Lausanne). 2024 Mar 14;15:1331012._x000D_ 7: Lin YW, Wang SS, Wen YC, Tung MC, Lee LM, Yang SF, Chien MH. Genetic Variations of Melatonin Receptor Type 1A are Associated with the Clinicopathologic Development of Urothelial Cell Carcinoma Int J Med Sci. 2017 Sep 4;14(11):1130-1135._x000D_ 8: Han D, Wang Y, Chen J, Zhang J, Yu P, Zhang R, Li S, Tao B, Wang Y, Qiu Y, Xu M, Gao E, Cao F. Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin-conferred cardioprotection against myocardial ischemia/reperfusion injury J Pineal Res. 2019 Aug;67(1):e12571._x000D_ 9: Li G, Zhang Y, Ni Y, Wang Y, Xu B, Guo X. Identification of a melatonin receptor type 1A gene (AccMTNR1A) in Apis cerana cerana and its possible involvement in the response to low temperature stress Naturwissenschaften. 2018 Mar 22;105(3-4):24._x000D_ 10: Emet M, Ozcan H, Ozel L, Yayla M, Halici Z, Hacimuftuoglu A. A Review of Melatonin, Its Receptors and Drugs Eurasian J Med. 2016 Jun;48(2):135-41. _x000D_ _x000D_ Products Related to Melatonin Receptor Type 1A (human recombinant) can be found at Proteins

• Short Description:

  Catalog Number: B2017259 (10 µg)_x000D_ Melatonin Receptor Type 1A (MT1 or MTNR1A) is a protein encoded by the MTNR1A gene. This receptor is one of the two high-affinity receptors for melatonin, a hormone that regulates sleep-wake cycles and other circadian rhythms. Recombinant technology allows scientists to produce this receptor protein in a controlled laboratory environment for various research purposes. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3