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AK963/40708899

CAT: 0804-HY-164374Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164374Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways[1].
CAS Number
445007-59-0
UNSPSC
12352005
Target
PAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ak963-40708899.html
Smiles
O=C(NC1=CC(C)=CC=C1C)NC2=CC=CC(C)=C2
Molecular Formula
C16H18N2O
Molecular Weight
254.33
References & Citations
[1]Ying Zhou, et al. Targeting PAK1 with the Small Molecule Drug AK963/40708899 Suppresses Gastric Cancer Cell Proliferation and Invasion by Downregulation of PAK1 Activity and PAK1-Related Signaling Pathways. Anat Rec (Hoboken) . 2019 Sep;302 (9) :1571-1579.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAK1

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CatalogName
T69243-01AK963

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