(S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc

• UNSPSC Description:

  (S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/s-protac-ptk6-ligand-o-4-4-dimethylpiperidine-boc.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@H]1N(C[C@@H](C1)O)C([C@@H](C(C)C)C2=CC(OCC3(CCN(CC3)C(OC(C)(C)C)=O)C)=NO2)=O)NCC(C=C4)=CC=C4C(SC=N5)=C5C

• Molecular Weight:

  695.87

• References & Citations:

  [1]Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported